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- John Lackey, P, Anaheim Angels
- Aaron Laffey, P, Cleveland Indians
- Bryan Lahair, 1B, Seattle Mariners
- Gerald Laird, C, Detroit Tigers
- Mike Lamb, 3B, Milwaukee Brewers
- Chris Lambert, P, Detroit Tigers
- Andrew Lambo, LF, Los Angeles Dodgers
- Jason Lane, RF, Toronto Blue Jays
- Ryan Langerhans, LF, Washington Nationals
- John Lannan, P, Washington Nationals
- Jared Lansford, P, Oakland Athletics
- Matt LaPorta, RF, Cleveland Indians
- Jeffrey Larish, 1B, Detroit Tigers
- Adam LaRoche, 1B, Pittsburgh Pirates
- Andy LaRoche, 3B, Pittsburgh Pirates
- Preston Larrison, P, Washington Nationals
- Jason LaRue, C, St. Louis Cardinals
- Jeramy Laster, CF, Detroit Tigers
- Matthew Latos, P, San Diego Padres
- Brett Lawrie, C, Milwaukee Brewers
- Brent Leach, P, Los Angeles Dodgers
- Brandon League, P, Toronto Blue Jays
- Wade Leblanc, P, San Diego Padres
- Sam Lecure, P, Cincinnati Reds
- Wil Ledezma, P, Washington Nationals
- Carlos Lee, LF, Houston Astros
- Cliff Lee, P, Cleveland Indians
- Derrek Lee, 1B, Chicago Cubs
- Dan Lehmann, C, Minnesota Twins
- Justin Lehr, P, Philadelphia Phillies
- Alex Leon, P, Oakland Athletics
- Justin Leone, 3B, New York Yankees
- Anthony Lerew, P, Atlanta Braves
- Chris Leroux, P, Florida Marlins
- Steve Lerud, C, Pittsburgh Pirates
- Jon Lester, P, Boston Red Sox
- Fred Lewis, LF, San Francisco Giants
- Jensen Lewis, P, Cleveland Indians
- Scott Lewis, P, Cleveland Indians
- Brad Lidge, P, Philadelphia Phillies
- Jon Lieber, P, Chicago Cubs
- Brent Lillibridge, SS, Chicago White Sox
- Ted Lilly, P, Chicago Cubs
- Che-Hsuan Lin, CF, Boston Red Sox
- Tim Lincecum, P, San Francisco Giants
- Brad Lincoln, P, Pittsburgh Pirates
- Mike Lincoln, P, Cincinnati Reds
- Adam Lind, LF, Toronto Blue Jays
- Joshua Lindblom, P, Los Angeles Dodgers
- Todd Linden, RF, New York Yankees
- Shane Lindsay, P, Colorado Rockies
- John Lindsey, 1B, Florida Marlins
- Matt Lindstrom, P, Florida Marlins
- Scott Linebrink, P, Chicago White Sox
- Jon Link, P, Chicago White Sox
- Francisco Liriano, P, Minnesota Twins
- Mario Lisson, 3B, Kansas City Royals
- Jesse Litsch, P, Toronto Blue Jays
- Wes Littleton, P, Boston Red Sox
- Radhames Liz, P, Baltimore Orioles
- Paul Lo_Duca, C, Florida Marlins
- Esteban Loaiza, P, Chicago White Sox
- Jose Lobaton, C, San Diego Padres
- Jeffrey Locke, P, Atlanta Braves
- Kameron Loe, P, Texas Rangers
- Chuck Lofgren, P, Cleveland Indians
- Boone Logan, P, Atlanta Braves
- Kyle Lohse, P, St. Louis Cardinals
- James Loney, 1B, Los Angeles Dodgers
- Evan Longoria, 3B, Tampa Bay Rays
- Braden Looper, P, Milwaukee Brewers
- Aquilino Lopez, P, Detroit Tigers
- Arturo Lopez, P, San Diego Padres
- Felipe Lopez, 2B, Arizona Diamondbacks
- Javier Lopez, P, Boston Red Sox
- Jose Lopez, 2B, Seattle Mariners
- Pedro Lopez, SS, Pittsburgh Pirates
- Rodrigo Lopez, P, Philadelphia Phillies
- Mike Loree, P, San Francisco Giants
- Mark Loretta, 2B, Los Angeles Dodgers
- Kyle Lotzkar, P, Cincinnati Reds
- Shane Loux, P, Anaheim Angels
- Derek Lowe, P, Atlanta Braves
- Mark Lowe, P, Seattle Mariners
- Mike Lowell, 3B, Boston Red Sox
- Devon Lowery, P, Kansas City Royals
- Marvin Lowrance, LF, Washington Nationals
- Jed Lowrie, SS, Boston Red Sox
- Noah Lowry, P, San Francisco Giants
- Chris Lubanski, LF, Kansas City Royals
- Jonathan Lucroy, C, Milwaukee Brewers
- Donny Lucy, C, Chicago White Sox
- Ryan Ludwick, RF, St. Louis Cardinals
- Jose Lugo, P, Seattle Mariners
- Julio Lugo, SS, Boston Red Sox
- Tyler Lumsden, P, Houston Astros
- Hector Luna, 3B, Los Angeles Dodgers
- Wayne Lydon, CF, Toronto Blue Jays
- Jordan Lyles, P, Houston Astros
- Brandon Lyon, P, Detroit Tigers
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