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- John Lackey, P, Anaheim Angels
- Timothy Ladd, P, Atlanta Braves
- Aaron Laffey, P, Cleveland Indians
- Pete Laforest, C, Philadelphia Phillies
- Eligio Lagua, P, Atlanta Braves
- Bryan LaHair, 1B, Seattle Mariners
- Gerald Laird, C, Texas Rangers
- Mike Lamb, 3B, Minnesota Twins
- Andrew Lambo, RF, Los Angeles Dodgers
- Jason Lane, RF, New York Yankees
- Ryan Langerhans, LF, Washington Nationals
- John Lannan, P, Washington Nationals
- Matt LaPorta, LF, Milwaukee Brewers
- Juan Lara, P, Cleveland Indians
- Jeffrey Larish, 1B, Detroit Tigers
- Adam LaRoche, 1B, Pittsburgh Pirates
- Andy LaRoche, 3B, Los Angeles Dodgers
- Jason LaRue, C, St. Louis Cardinals
- Quincy Latimore, CF, Pittsburgh Pirates
- Matthew Latos, P, San Diego Padres
- Brian Lawrence, P, New York Mets
- Brandon League, P, Toronto Blue Jays
- Wade Leblanc, P, San Diego Padres
- Luis Lebron, P, Baltimore Orioles
- Matthew LeCroy, DH, Minnesota Twins
- Sam Lecure, P, Cincinnati Reds
- Ricky Ledee, DH, New York Mets
- Wilfredo Ledezma, P, San Diego Padres
- Carlos Lee, LF, Houston Astros
- Cliff Lee, P, Cleveland Indians
- Derrek Lee, 1B, Chicago Cubs
- Justin Lehr, P, Seattle Mariners
- Jon Leicester, P, Baltimore Orioles
- Marcus Lemon, SS, Texas Rangers
- Anthony Lerew, P, Atlanta Braves
- Jon Lester, P, Boston Red Sox
- Colby Lewis, P, Kansas City Royals
- Fred Lewis, LF, San Francisco Giants
- Jensen Lewis, P, Cleveland Indians
- Scott Lewis, P, Cleveland Indians
- Alex Liddi, 3B, Seattle Mariners
- Brad Lidge, P, Philadelphia Phillies
- Jon Lieber, P, Chicago Cubs
- Mike Lieberthal, C, Los Angeles Dodgers
- Brent Lillibridge, SS, Atlanta Braves
- Ted Lilly, P, Chicago Cubs
- Che-Hsuan Lin, CF, Boston Red Sox
- Tim Lincecum, P, San Francisco Giants
- Adam Lind, LF, Toronto Blue Jays
- Todd Linden, DH, Florida Marlins
- Matt Lindstrom, P, Florida Marlins
- Scott Linebrink, P, Chicago White Sox
- Francisco Liriano, P, Minnesota Twins
- Erik Lis, LF, Minnesota Twins
- Mario Lisson, 3B, Kansas City Royals
- Jesse Litsch, P, Toronto Blue Jays
- Wes Littleton, P, Texas Rangers
- Bobby Livingston, P, Cincinnati Reds
- Radhames Liz, P, Baltimore Orioles
- Ching Lo, P, Colorado Rockies
- Kuo-Hui Lo, LF, Seattle Mariners
- Paul Lo_Duca, C, Washington Nationals
- Esteban Loaiza, P, Los Angeles Dodgers
- Jeffrey Locke, P, Atlanta Braves
- Kameron Loe, P, Texas Rangers
- Adam Loewen, P, Baltimore Orioles
- Chuck Lofgren, P, Cleveland Indians
- Kenny Lofton, CF, Cleveland Indians
- Boone Logan, P, Chicago White Sox
- Nook Logan, CF, Washington Nationals
- Kyle Lohse, P, St. Louis Cardinals
- George Lombard, LF, Los Angeles Dodgers
- James Loney, 1B, Los Angeles Dodgers
- Evan Longoria, 3B, Tampa Bay Rays
- Braden Looper, P, St. Louis Cardinals
- Aquilino Lopez, P, Detroit Tigers
- Felipe Lopez, SS, Washington Nationals
- Javier Lopez, P, Boston Red Sox
- Javy Lopez, C, Atlanta Braves
- Jose Lopez, 2B, Seattle Mariners
- Pedro Lopez, SS, Cincinnati Reds
- Rodrigo Lopez, P, Colorado Rockies
- Mark Loretta, 2B, Houston Astros
- Kyle Lotzkar, P, Cincinnati Reds
- Derek Lowe, P, Los Angeles Dodgers
- Mark Lowe, P, Seattle Mariners
- Mike Lowell, 3B, Boston Red Sox
- Jed Lowrie, SS, Boston Red Sox
- Noah Lowry, P, San Francisco Giants
- Chris Lubanski, LF, Kansas City Royals
- Jonathan Lucroy, C, Milwaukee Brewers
- Donny Lucy, C, Chicago White Sox
- Ryan Ludwick, LF, St. Louis Cardinals
- Julio Lugo, SS, Boston Red Sox
- Ruddy Lugo, P, Oakland Athletics
- Hector Luna, SS, Toronto Blue Jays
- Brandon Lyon, P, Arizona Diamondbacks
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