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- James D'Antona, 3B, Arizona Diamondbacks
- Travis D'Arnaud, C, Philadelphia Phillies
- Zachary Daeges, LF, Boston Red Sox
- Johnny Damon, CF, New York Yankees
- Michael Daniel, RF, Washington Nationals
- John Danks, P, Chicago White Sox
- Jeff DaVanon, CF, San Diego Padres
- David Davidson, P, Pittsburgh Pirates
- Kyle Davies, P, Kansas City Royals
- Adam Davis, 2B, Cleveland Indians
- Ben Davis, C, Baltimore Orioles
- Chris Davis, 3B, Texas Rangers
- Doug Davis, P, Arizona Diamondbacks
- Jason Davis, P, Seattle Mariners
- Kane Davis, P, Philadelphia Phillies
- Leonard Davis, 3B, Washington Nationals
- Rajai Davis, CF, San Francisco Giants
- Wade Davis, P, Tampa Bay Rays
- Dewon Day, P, Chicago White Sox
- Zach Day, P, Minnesota Twins
- Alejandro De_Aza, CF, Florida Marlins
- Yurendell de_Caster, 1B, Pittsburgh Pirates
- Ivan De_Jesus, SS, Los Angeles Dodgers
- Eulogio De_La_Cruz, P, Florida Marlins
- Jose De_La_Cruz, P, Seattle Mariners
- Jorge De_La_Rosa, P, Kansas City Royals
- Faustino De_Los_Santos, P, Oakland Athletics
- Samuel Deduno, P, Colorado Rockies
- Mike DeJean, P, Houston Astros
- David DeJesus, CF, Kansas City Royals
- Jason Delaney, LF, Pittsburgh Pirates
- Manny Delcarmen, P, Boston Red Sox
- Carlos Delgado, 1B, New York Mets
- David Dellucci, LF, Cleveland Indians
- Collin DeLome, CF, Houston Astros
- Ryan Dempster, P, Chicago Cubs
- Chris Denorfia, CF, Oakland Athletics
- Ryan Dent, 2B, Boston Red Sox
- Julio DePaula, P, Minnesota Twins
- Mark DeRosa, 2B, Chicago Cubs
- Matt DeSalvo, P, New York Yankees
- Ian Desmond, SS, Washington Nationals
- Elmer Dessens, P, Pittsburgh Pirates
- Ross Detwiler, P, Washington Nationals
- Michael Devaney, P, New York Mets
- Joey Devine, P, Oakland Athletics
- Blake Dewitt, 3B, Los Angeles Dodgers
- Thomas Diamond, P, Texas Rangers
- Matt Diaz, LF, Atlanta Braves
- Robinzon Diaz, C, Toronto Blue Jays
- Victor Diaz, RF, Houston Astros
- Chris Dickerson, CF, Cincinnati Reds
- R.A. Dickey, P, Seattle Mariners
- Mark DiFelice, P, Milwaukee Brewers
- Mike DiFelice, C, Tampa Bay Rays
- Tim Dillard, P, Milwaukee Brewers
- Joe Dillon, 3B, Milwaukee Brewers
- Lenny DiNardo, P, Oakland Athletics
- Brian Dinkelman, 2B, Minnesota Twins
- Greg Dobbs, 3B, Philadelphia Phillies
- Scott Dohmann, P, Tampa Bay Rays
- Matt Dominguez, 3B, Florida Marlins
- Jason Donald, SS, Philadelphia Phillies
- Josh Donaldson, C, Chicago Cubs
- Brendan Donnelly, P, Boston Red Sox
- Sean Doolittle, 1B, Oakland Athletics
- Brian Dopirak, 1B, Chicago Cubs
- Daniel Dorn, LF, Cincinnati Reds
- Octavio Dotel, P, Chicago White Sox
- Ryan Doumit, C, Pittsburgh Pirates
- Scott Downs, P, Toronto Blue Jays
- Cory Doyne, P, Baltimore Orioles
- Kyle Drabek, P, Philadelphia Phillies
- John Drennen, CF, Cleveland Indians
- J.D. Drew, RF, Boston Red Sox
- Stephen Drew, SS, Arizona Diamondbacks
- Travis Driskill, P, Houston Astros
- Michael Dubee, P, Chicago White Sox
- Justin Duchscherer, P, Oakland Athletics
- Brandon Duckworth, P, Kansas City Royals
- Brian Duensing, P, Minnesota Twins
- Chris Duffy, CF, Pittsburgh Pirates
- Daniel Duffy, P, Kansas City Royals
- Zach Duke, P, Pittsburgh Pirates
- Elijah Dukes, CF, Washington Nationals
- Phil Dumatrait, P, Pittsburgh Pirates
- Chris Duncan, LF, St. Louis Cardinals
- Shelley Duncan, 1B, New York Yankees
- Cory Dunlap, 1B, Los Angeles Dodgers
- Adam Dunn, LF, Cincinnati Reds
- Michael Dunn, P, New York Yankees
- German Duran, 2B, Texas Rangers
- Chad Durbin, P, Philadelphia Phillies
- J.D. Durbin, P, Philadelphia Phillies
- Ray Durham, 2B, San Francisco Giants
- Jermaine Dye, RF, Chicago White Sox
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