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- James D'Antona, 3B, Arizona Diamondbacks
- Chase D'Arnaud, SS, Pittsburgh Pirates
- Zachary Daeges, LF, Boston Red Sox
- Casey Daigle, P, Texas Rangers
- Matt Daley, P, Colorado Rockies
- Johnny Damon, LF, New York Yankees
- Michael Daniel, CF, Washington Nationals
- John Danks, P, Chicago White Sox
- Rudy Darrow, P, Detroit Tigers
- Daniel Davidson, P, Anaheim Angels
- David Davidson, P, Pittsburgh Pirates
- Kyle Davies, P, Kansas City Royals
- Blake Davis, SS, Baltimore Orioles
- Bradley Davis, C, Florida Marlins
- Chris Davis, 1B, Texas Rangers
- Doug Davis, P, Arizona Diamondbacks
- Isaac Davis, 1B, New York Mets
- Jason Davis, P, Pittsburgh Pirates
- Leonard Davis, 3B, Washington Nationals
- Rajai Davis, CF, Oakland Athletics
- Wade Davis, P, Tampa Bay Rays
- Dewon Day, P, Tampa Bay Rays
- Alejandro De_Aza, CF, Florida Marlins
- Ivan De_Jesus, SS, Los Angeles Dodgers
- Jordan De_Jong, P, Toronto Blue Jays
- Eulogio De_La_Cruz, P, Florida Marlins
- Kelvin De_La_Cruz, P, Cleveland Indians
- Luis De_La_Cruz, C, St. Louis Cardinals
- Jorge De_La_Rosa, P, Colorado Rockies
- Wilkins De_La_Rosa, P, New York Yankees
- Gilbert de_la_Vara, P, Houston Astros
- Anel De_Los_Santos, C, Anaheim Angels
- Valerio De_Los_Santos, P, New York Mets
- Philip Dean, P, Washington Nationals
- Nick Debarr, P, Los Angeles Dodgers
- Samuel Deduno, P, Colorado Rockies
- Doug Deeds, RF, Chicago Cubs
- Gabe Dehoyos, P, San Diego Padres
- David DeJesus, CF, Kansas City Royals
- Jason Delaney, 1B, Pittsburgh Pirates
- Robert Delaney, P, Minnesota Twins
- Manny Delcarmen, P, Boston Red Sox
- Carlos Delgado, 1B, New York Mets
- Jesus Delgado, P, Florida Marlins
- Randall Delgado, P, Atlanta Braves
- David Dellucci, LF, Cleveland Indians
- Collin Delome, LF, Houston Astros
- Samuel DeMel, P, Oakland Athletics
- Ryan Dempster, P, Chicago Cubs
- Travis Denker, 2B, San Diego Padres
- Chris Denorfia, CF, Oakland Athletics
- Chris Denove, C, Cincinnati Reds
- Julio Depaula, P, Tampa Bay Rays
- Mark DeRosa, 2B, Cleveland Indians
- Matt DeSalvo, P, New York Mets
- Ian Desmond, SS, Washington Nationals
- Elmer Dessens, P, New York Mets
- Ross Detwiler, P, Washington Nationals
- Brett DeVall, P, Atlanta Braves
- Joey Devine, P, Oakland Athletics
- Blake Dewitt, 3B, Los Angeles Dodgers
- Fredy Deza, P, Baltimore Orioles
- Thomas Diamond, P, Texas Rangers
- Argenis Diaz, SS, Boston Red Sox
- Jose Diaz, P, Texas Rangers
- Matt Diaz, LF, Atlanta Braves
- Robinzon Diaz, C, Pittsburgh Pirates
- Victor Diaz, DH, Seattle Mariners
- Chris Dickerson, CF, Cincinnati Reds
- Joseph Dickerson, RF, Kansas City Royals
- R.A. Dickey, P, Minnesota Twins
- Mark DiFelice, P, Milwaukee Brewers
- Mike DiFelice, C, Tampa Bay Rays
- Tim Dillard, P, Milwaukee Brewers
- Joe Dillon, 3B, Oakland Athletics
- Lenny DiNardo, P, Kansas City Royals
- Phil Disher, 1B, Houston Astros
- Greg Dobbs, 3B, Philadelphia Phillies
- Scott Dohmann, P, Tampa Bay Rays
- Freddy Dolsi, P, Detroit Tigers
- Matt Dominguez, 3B, Florida Marlins
- Adam Donachie, C, Baltimore Orioles
- Jason Donald, SS, Philadelphia Phillies
- Josh Donaldson, C, Oakland Athletics
- Brendan Donnelly, P, Texas Rangers
- Sean Doolittle, 1B, Oakland Athletics
- Brian Dopirak, 1B, Toronto Blue Jays
- Rich Dorman, P, Seattle Mariners
- Daniel Dorn, LF, Cincinnati Reds
- Octavio Dotel, P, Chicago White Sox
- Felix Doubront, P, Boston Red Sox
- Ryan Doumit, C, Pittsburgh Pirates
- Matthew Downs, 2B, San Francisco Giants
- Scott Downs, P, Toronto Blue Jays
- Kyle Drabek, P, Philadelphia Phillies
- J.D. Drew, RF, Boston Red Sox
- Stephen Drew, SS, Arizona Diamondbacks
- Scot Drucker, P, Detroit Tigers
- Jose Duarte, CF, Kansas City Royals
- Michael Dubee, P, Chicago White Sox
- Jason Dubois, RF, Chicago Cubs
- Justin Duchscherer, P, Oakland Athletics
- Brandon Duckworth, P, Kansas City Royals
- Brian Duensing, P, Minnesota Twins
- Chris Duffy, CF, Milwaukee Brewers
- Daniel Duffy, P, Kansas City Royals
- Zach Duke, P, Pittsburgh Pirates
- Elijah Dukes, RF, Washington Nationals
- Phil Dumatrait, P, Pittsburgh Pirates
- Chris Duncan, LF, St. Louis Cardinals
- Shelley Duncan, 1B, New York Yankees
- Adam Dunn, LF, Washington Nationals
- Michael Dunn, P, New York Yankees
- German Duran, 2B, Texas Rangers
- Luis Durango, DH, San Diego Padres
- Chad Durbin, P, Philadelphia Phillies
- Ray Durham, 2B, Milwaukee Brewers
- Jermaine Dye, RF, Chicago White Sox
- Cutter Dykstra, CF, Milwaukee Brewers
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